Beta-blocker treatment in the critically ill: a systematic review and meta-analysis.

ABSTRACT:

Background

Critical illness may lead to activation of the sympathetic system. The sympathetic stimulation may be further increased by exogenous catecholamines, such as vasopressors and inotropes. Excessive adrenergic stress has been associated with organ dysfunction and higher mortality. β-Blockers may reduce the adrenergic burden, but they may also compromise perfusion to vital organs thus worsening organ dysfunction. To assess the effect of treatment with β-blockers in critically ill adults, we conducted a systematic review and meta-analysis of randomized controlled trials.

Materials and methods

We conducted a search from three major databases: Ovid Medline, the Cochrane Central Register for Controlled Trials and Scopus database. Two independent reviewers scr

SUBMITTER: Heliste M 

PROVIDER: S-EPMC9291706 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature