Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood.

ABSTRACT:

Background

Polygenic risk scores (PRSs) operationalize genetic propensity toward a particular mental disorder and hold promise as early predictors of psychopathology, but before a PRS can be used clinically, explanatory power must be increased and the specificity for a psychiatric domain established. To enable early detection, it is crucial to study these psychometric properties in childhood. We examined whether PRSs associate more with general or with specific psychopathology in school-aged children. Additionally, we tested whether psychiatric PRSs can be combined into a multi-PRS score for improved performance.

Methods

We computed 16 PRSs based on GWASs of psychiatric phenotypes, but also neuroticism and cognitive ability, in mostly adult populations. Study participants we

SUBMITTER: Neumann A 

PROVIDER: S-EPMC9291767 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature