Alcohol use and brain morphology in adolescence: A longitudinal study in three different cohorts.

ABSTRACT: Alcohol consumption is commonly initiated during adolescence, but the effects on human brain development remain unknown. In this multisite study, we investigated the longitudinal associations of adolescent alcohol use and brain morphology. Three longitudinal cohorts in the Netherlands (BrainScale n = 200, BrainTime n = 239 and a subsample of the Generation R study n = 318) of typically developing participants aged between 8 and 29 years were included. Adolescent alcohol use was self-reported. Longitudinal neuroimaging data were collected for at least two time points. Processing pipelines and statistical analyses were harmonized across cohorts. Main outcomes were global and regional brain volumes, which were a priori selected. Linear mixed effect models were used to test main effects of alc

SUBMITTER: El Marroun H 

PROVIDER: S-EPMC9291789 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature