Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease.

ABSTRACT:

Aims

The prevalence of vitamin D deficiency is high in children with chronic kidney disease (CKD). However, current dosing recommendations are based on limited pharmacokinetic (PK) data. This study aimed to develop a population PK model of colecalciferol that can be used to optimise colecalciferol dosing in this population.

Methods

Data from 83 children with CKD were used to develop a population PK model using a nonlinear mixed effects modelling approach. Serum creatinine and type of kidney disease (glomerular vs. nonglomerular disease) were investigated as covariates, and optimal dosing was determined based on achieving and maintaining 25-hydroxyvitamin D (25(OH)D) concentration of 30-48 ng/mL.

Results

The time course of 25(OH)D concentrations was best described by a

SUBMITTER: Wan M 

PROVIDER: S-EPMC9291800 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature