Treatment induced clearance of hepatitis E viruses by interferon-lambda in liver-humanized mice.

ABSTRACT:

Background

Hepatitis E viruses (HEV) are an underestimated global cause of enterically transmitted viral hepatitis, which may persist in immunocompromised hosts, posing a risk for progressive liver fibrosis with limited treatment options. We previously established liver-humanized mice as a model for chronic HEV infections, which can be cleared by a 2-week pegylated (peg)-Interferon(IFN)α treatment course. However, severe side effects may hamper the use of IFNα in immunocompromised transplant recipient patients. IFNλ may be a valuable alternative, as its receptor is less ubiquitously expressed.

Aims

In this study, we assess the in vitro and in vivo potency of pegIFNλ to induce innate immune signalling in liver cells and to clear a persistent HEV infection in liver-humanized m

SUBMITTER: Sari G 

PROVIDER: S-EPMC9291846 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature