Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes.

ABSTRACT:

Background

Hypoglycemia is the most common complication in insulin treated diabetes. Though mostly mild, it can be fatal in rare cases: It is hypothesized that hypoglycemia related QTc prolongation contributes to cardiac arrhythmia.

Objective

To evaluate influence of nocturnal hypoglycemia on QTc and heart rate variability (HRV) in children with T1D.

Methods

Children and adolescents with T1D for at least 6 months participated in an observational study using continuous glucose monitoring (CGM) and Holter electrocardiogram for five consecutive nights. Mean QTc was calculated for episodes of nocturnal hypoglycemia (<3.7 mmol/L) and compared to periods of the same duration preceding hypoglycemia. HRV (RMSSD, low and high frequency power LF and HF) was analyzed for differe

SUBMITTER: Bachmann S 

PROVIDER: S-EPMC9291884 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature