Burkholderia multivorans requires species-specific GltJK for entry of a contact-dependent growth inhibition system protein.

ABSTRACT: Interbacterial antagonism and communication are driving forces behind microbial community development. In many Gram-negative bacteria, contact-dependent growth inhibition (CDI) systems contribute to these microbial interactions. CDI systems deliver the toxic C-terminus of a large surface exposed protein to the cytoplasm of neighboring bacteria upon cell-contact. Termed the BcpA-CT, import of this toxic effector domain is mediated by specific, yet largely unknown receptors on the recipient cell outer and inner membranes. In this study, we demonstrated that cytoplasmic membrane proteins GltJK, components of a predicted ABC-type transporter, are required for entry of CDI system protein BcpA-2 into Burkholderia multivorans recipient cells. Consistent with current CDI models, gltJK were also re

SUBMITTER: Myers-Morales T 

PROVIDER: S-EPMC9291907 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature