Longitudinal Changes in Hippocampal Network Connectivity in Alzheimer's Disease.

ABSTRACT:

Objective

The hippocampus is connected to 2 distinct cortical brain networks, the posterior-medial and the anterior-temporal networks, involving different medial temporal lobe (MTL) subregions. The aim of this study was to assess the functional alterations of these 2 networks, their changes over time, and links to cognition in Alzheimer's disease.

Methods

We assessed MTL connectivity in 53 amyloid-β-positive patients with mild cognitive impairment and AD dementia and 68 healthy elderly controls, using resting-state functional magnetic resonance imaging, cross-sectionally and longitudinally. First, we compared the functional connectivity of the posterior-medial and anterior-temporal networks within the control group to highlight their specificities. Second, we compared the co

SUBMITTER: Dautricourt S 

PROVIDER: S-EPMC9291910 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature