Association between low fetal fraction in cell-free DNA testing and adverse pregnancy outcome: A systematic review.

ABSTRACT:

Objective

Low fetal fraction (LFF) in prenatal cell-free DNA (cfDNA) testing is an important cause of test failure and no-call results. LFF might reflect early abnormal placentation and therefore be associated with adverse pregnancy outcome. Here, we review the available literature on the relationship between LFF in cfDNA testing and adverse pregnancy outcome.

Method

A systematic literature search was conducted in MEDLINE and EMBASE up to November 1, 2020.

Results

Five studies met the criteria for inclusion; all were retrospective observational cohort studies. The cohort sizes ranged from 370 to 6375 pregnancies, with all tests performed in the first trimester or early second trimester. A 4% cutoff for LFF was used in two studies, two studies used the 5th and 25th per

SUBMITTER: Scheffer PG 

PROVIDER: S-EPMC9292009 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature