Ontology highlight
ABSTRACT:
SUBMITTER: Schwarz C
PROVIDER: S-EPMC9292010 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Schwarz Christoph C Mahr Benedikt B Muckenhuber Moritz M Weijler Anna Marianne AM Unger Lukas Walter LW Pilat Nina N Latus Michaela M Regele Heinz H Wekerle Thomas T
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20210823 11
CTLA4Ig has been shown to improve kidney allograft function, but an increased frequency of early rejection episodes poses a major obstacle for more widespread clinical use. The deleterious effect of CTLA4Ig on Treg numbers provides a possible explanation for graft injury. Therefore, we aimed at improving CTLA4Ig's efficacy by therapeutically increasing the number of Tregs. Murine cardiac allograft transplantation (BALB/c to B6) was performed under CTLA4Ig therapy modeled after the clinically ap ...[more]