Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.

ABSTRACT:

Introduction

Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20-year follow-ups.

Methods

In the Whitehall II prospective cohort study proteins were measured using SOMAscan technology. Cognitive performance was tested five times over 20 years. Linkage to electronic health records identified incident dementia. The results were replicated in the Atherosclerosis Risk in Communities (ARIC) study.

Results

Fifteen non-amyloid/non-tau-related proteins were associated with cognitive decline and dementia, were consistently identified in b

SUBMITTER: Lindbohm JV 

PROVIDER: S-EPMC9292245 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature