Defect distribution index: A novel metric for functional lung MRI in cystic fibrosis.

ABSTRACT:

Purpose

Lung impairment from functional MRI is frequently assessed as defect percentage. The defect distribution, however, is currently not quantified. The purpose of this work was to develop a novel measure that quantifies how clustered or scattered defects in functional lung MRI appear, and to evaluate it in pediatric cystic fibrosis.

Theory

The defect distribution index (DDI) calculates a score for each lung voxel categorized as defected. The index increases according to how densely and how far an expanding circle around a defect voxel contains more than 50% defect voxels.

Methods

Fractional ventilation and perfusion maps of 53 children with cystic fibrosis were previously acquired with matrix pencil decomposition MRI. In this work, the DDI is compared to a visual

SUBMITTER: Valk A 

PROVIDER: S-EPMC9292253 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature