White matter hyperintensity topography in Alzheimer's disease and links to cognition.

ABSTRACT:

Introduction

White matter hyperintensities (WMH) are often described in Alzheimer's disease (AD), but their topography and specific relationships with cognition remain unclear.

Methods

Regional WMH were estimated in 54 cognitively impaired amyloid beta-positive AD (Aβpos-AD), compared to 40 cognitively unimpaired amyloid beta-negative older controls (Aβneg-controls) matched for vascular risk factors. The cross-sectional association between regional WMH volume and cognition was assessed within each group, controlling for cerebral amyloid burden, global cortical atrophy, and hippocampal atrophy.

Results

WMH volume was larger in Aβpos-AD compared to Aβneg-controls in all regions, with the greatest changes in the splenium of the corpus callosum (S-CC). In Aβpos-AD patient

SUBMITTER: Garnier-Crussard A 

PROVIDER: S-EPMC9292254 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature