Intimate genetic relationships and fungicide resistance in multiple strains of Aspergillus fumigatus isolated from a plant bulb.

ABSTRACT: Fungal infections are increasingly dangerous because of environmentally dispersed resistance to antifungal drugs. Azoles are commonly used antifungal drugs, but they are also used as fungicides in agriculture, which may enable enrichment of azole-resistant strains of the human pathogen Aspergillus fumigatus in the environment. Understanding of environmental dissemination and enrichment of genetic variation associated with azole resistance in A. fumigatus is required to suppress resistant strains. Here, we focused on eight strains of azole-resistant A. fumigatus isolated from a single tulip bulb for sale in Japan. This set includes strains with TR₃₄ /L98H/T289A/I364V/G448S and TR₄₆ /Y121F/T289A/S363P/I364V/G448S mutations in the cyp51A gene, which showed higher toleran

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC9292267 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature