Zfhx3 modulates retinal sensitivity and circadian responses to light.

ABSTRACT: Mutations in transcription factors often exhibit pleiotropic effects related to their complex expression patterns and multiple regulatory targets. One such mutation in the zinc finger homeobox 3 (ZFHX3) transcription factor, short circuit (Sci, Zfhx3^Sci/+ ), is associated with significant circadian deficits in mice. However, given evidence of its retinal expression, we set out to establish the effects of the mutation on retinal function using molecular, cellular, behavioral and electrophysiological measures. Immunohistochemistry confirms the expression of ZFHX3 in multiple retinal cell types, including GABAergic amacrine cells and retinal ganglion cells including intrinsically photosensitive retinal ganglion cells (ipRGCs). Zfhx3^Sci/+ mutants display reduced light res

SUBMITTER: Hughes S 

PROVIDER: S-EPMC9292409 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature