Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study.

ABSTRACT:

Background and aims

Ibogaine is an indole alkaloid used in rituals of the African Bwiti tribe. It is also used in non-medical settings to treat addiction. However, ibogaine has been linked to several deaths, mainly due to cardiac events called torsades des pointes preceded by QTc prolongation as well as other safety concerns. This study aimed to evaluate the cardiac, cerebellar and psychomimetic safety of ibogaine in patients with opioid use disorder.

Design

A descriptive open-label observational study.

Setting

Department of psychiatry in a university medical center, the Netherlands.

Participants

Patients with opioid use disorder (n = 14) on opioid maintenance treatment with a lasting wish for abstinence, who failed to reach abstinence with standard care.

In

SUBMITTER: Knuijver T 

PROVIDER: S-EPMC9292417 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature