Subthalamic and Pallidal Stimulations in Patients with Parkinson's Disease: Common and Dissociable Connections.

ABSTRACT:

Objective

The subthalamic nucleus (STN) and internal globus pallidus (GPi) are the most effective targets in deep brain stimulation (DBS) for Parkinson's disease (PD). However, the common and specific effects on brain connectivity of stimulating the 2 nuclei remain unclear.

Methods

Patients with PD receiving STN-DBS (n = 27, 6 women, mean age 64.8 years) or GPi-DBS (n = 28, 13 women, mean age 64.6 years) were recruited for resting-state functional magnetic resonance imaging to assess the effects of STN-DBS and GPi-DBS on brain functional dynamics.

Results

The functional connectivity both between the somatosensory-motor cortices and thalamus, and between the somatosensory-motor cortices and cerebellum decreased in the DBS-on state compared with the off state (p < 0.05)

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9292442 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature