Preexisting Bipolar Disorder Influences the Subsequent Phenotype of Parkinson's Disease.

ABSTRACT:

Background

Patients with bipolar spectrum disorders (BSDs) exhibit an increased risk of Parkinson's disease (PD).

Objective

The aim is to investigate whether a previous diagnosis of BSDs influences the phenotype of PD.

Methods

Of 2660 PD patients followed for at least 6 years (6-27), 250 (BSD-PD) had BSDs, 6-20 years before PD diagnosis; 48%-43% had a PD or BSD family history, and 34 carried glucocerebrosidase (GBA) and Parkin (PRKN) mutations. The cohort was split into a subset of 213 BSD-PD patients, compared with 426 matched PD patients without BSDs, and a subset of 34 BSD-PD and 79 PD patients carrying GBA or PRKN mutations. Carriers of mutations absent in BSD-PD patients and of synuclein triplication were excluded. Structured clinical interviews and mood disorder

SUBMITTER: Onofrj M 

PROVIDER: S-EPMC9292484 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature