Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.

ABSTRACT:

Background

The TCGA molecular groups of endometrial carcinoma are "POLE-mutated" (POLEmut), "microsatellite-instable/mismatch repair-deficient" (MSI/MMRd), "TP53-mutated/p53-abnormal" (TP53mut/p53abn), and "no specific molecular profile" (NSMP).

Objective

Prognostic assessment of the TCGA groups in uterine carcinosarcoma (UCS).

Search strategy

Systematic review from January 2000 to January 2021.

Selection criteria

Studies assessing the TCGA groups in UCS.

Data collection and analysis

Progression-free survival (PFS) and overall survival (OS) were assessed by Kaplan-Meier and Cox analyses (reference: TP53mut/p53abn group) and compared with endometrioid and serous carcinomas (original TCGA cohort), with a significant P < 0.050.

Main results

Five stud

SUBMITTER: Travaglino A 

PROVIDER: S-EPMC9292561 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature