Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans.

ABSTRACT: A previous study in 356 healthy Finnish volunteers showed that glycochenodeoxycholate 3-O-glucuronide (GCDCA-3G) and glycodeoxycholate 3-O-glucuronide (GDCA-3G) are promising biomarkers of organic anion transporting polypeptide 1B1 (OATP1B1). In the same cohort, we now evaluated the performances of two other OATP1B1 biomarkers, coproporphyrin I (CPI) and III (CPIII), and compared them with GCDCA-3G and GDCA-3G. Based on decreased (*5 and *15) and increased (*14 and *20) function SLCO1B1 haplotypes, we stratified the participants to poor, decreased, normal, increased, and highly increased OATP1B1 function groups. Fasting plasma CPI concentration was 68% higher in the poor (95% confidence interval, 44%, 97%; P = 1.74 × 10^-10 ), 7% higher in the decreased (0%, 15%; P = 0.0385), 10%

SUBMITTER: Neuvonen M 

PROVIDER: S-EPMC9292572 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature