Vitreous proteomics, a gateway to improved understanding and stratification of diverse uveitis aetiologies.

ABSTRACT:

Purpose

The vitreous proteome might provide an attractive gateway to discriminate between various uveitis aetiologies and gain novel insights into the underlying pathophysiological processes. Here, we investigated 180 vitreous proteins to discover novel biomarkers and broaden disease insights by comparing (1). primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies, (2). sarcoid uveitis versus tuberculosis (TB)-associated uveitis and (3). granulomatous (sarcoid and TB) uveitis versus other aetiologies.

Methods

Vitreous protein levels were determined by proximity extension assay in 47 patients with intraocular inflammation and a prestudy diagnosis (cohort 1; training) and 22 patients with a blinded diagnosis (cohort 2; validation). Differentially expressed proteins i

SUBMITTER: Schrijver B 

PROVIDER: S-EPMC9292680 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature