Advances in the development of Salmonella-based vaccine strategies for protection against Salmonellosis in humans.

ABSTRACT: Salmonella spp. are important human pathogens globally causing millions of cases of typhoid fever and non-typhoidal salmonellosis annually. There are only a few vaccines licensed for use in humans which all target Salmonella enterica serovar Typhi. Vaccine development is hampered by antigenic diversity between the thousands of serovars capable of causing infection in humans. However, a number of attenuated candidate vaccine strains are currently being developed. As facultative intracellular pathogens with multiple systems for transporting effector proteins to host cells, attenuated Salmonella strains can also serve as ideal tools for the delivery of foreign antigens to create multivalent live carrier vaccines for simultaneous immunization against several unrelated pathogens. Further, the e

SUBMITTER: Sears KT 

PROVIDER: S-EPMC9292744 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature