Clinicopathological characteristics of early onset colorectal cancer.

ABSTRACT:

Background

The rising incidence of early onset colorectal cancer (EOCRC) might reflect a novel tumour entity.

Aims

To evaluate clinicopathological characteristics of sporadic EOCRC (in patients < 50 years old) and investigate changes over time METHODS: All patients with sporadic EOCRC between 1989 and 2016 were included and divided by age: 20-29 years (group I), 30-39 years (group II) and 40-49 years (group III).

Results

We included 6400 patients. The presence of signet-ring cells and more poorly differentiated tumours were more common in the younger age groups: 5.4% and 3.7% for signet-ring cells in group I and II vs 1.4% in group III (P < 0.01), and 28.5% and 20.3% for poorly differentiated in group I and II vs 16.6% in group III, (P < 0.01 group I; P = 0.07 group I

SUBMITTER: Vuik FER 

PROVIDER: S-EPMC9292775 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature