Overconnectivity of the right Heschl's and inferior temporal gyrus correlates with symptom severity in preschoolers with autism spectrum disorder.

ABSTRACT: Previous studies have reported varying findings regarding the association of brain connectivity in autism spectrum disorder (ASD) with overconnectivity, underconnectivity, or both. Despite the emerging understanding that ASD is a developmental disconnection syndrome, very little is known about structural brain networks in preschool-aged children with low-functioning ASD. We aimed to investigate the structural brain connectivity of low-functioning ASD using diffusion magnetic resonance imaging and graph theory to examine alterations in different brain network topologies and identify any correlations with the clinical severity of ASD in preschool-aged children. Fifty-two preschool-aged children (28 with ASD and 24 with typical development) were included in the analysis. Graph-based network a

SUBMITTER: Kim D 

PROVIDER: S-EPMC9292809 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature