Neural correlates of the impulse dyscontrol domain of mild behavioral impairment.

ABSTRACT:

Objectives

Agitation and aggression are common in dementia and pre-dementia. The dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the impulse dyscontrol domain. However, the neural circuitry associated with impulse dyscontrol in neurodegenerative disease is not well understood. The objective of this work was to investigate if regional micro- and macro-structural brain properties were associated with impulse dyscontrol symptoms in older adults with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD).

Methods

Clinical, neuropsychiatric, and T1-weighted and diffusion-tensor magnetic resonance imaging (DTI) data from 80 individuals with and 123 individuals without impulse dyscontrol were obtained from the AD Neuroimaging In

SUBMITTER: Gill S 

PROVIDER: S-EPMC9292816 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature