Semi-quantitative histology confirms that the macrophage is the predominant cell type in metal-on-metal hip tissues.

ABSTRACT: Numerous studies have examined the histology of metal-on-metal hip tissues for evidence of a dose response to metal wear but have often reported inconclusive or contradictory findings. The aim of the present study was to address these discrepancies using multiple histological scoring methods to characterize the tissue features of one large group of revised metal-on-metal total hips. Periprosthetic tissues from 165 metal-on-metal hip revisions were examined for features of aseptic lymphocytic vasculitis associated lesions (ALVAL) as rated using two scoring systems as well as rankings for macrophage and lymphocyte numbers, intracellular wear debris and necrosis. Correlations between histological features and clinical variables including gender and time to revision and implant variables inclu

SUBMITTER: Campbell P 

PROVIDER: S-EPMC9292819 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature