Suicidality and self-injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing.

ABSTRACT:

Objective

Meta-analyses have established a heightened risk of suicidality for youth treated with selective serotonin reuptake inhibitors (SSRIs). The present study investigates the risk and possible predictors of suicidality and non-suicidal self-injury (NSSI) associated with SSRI treatment in a clinical sample of children and adolescents.

Methods

An observational, longitudinal, retrospective study using a within-subject study design including in- and outpatients aged 0-17 years treated with SSRIs. Data were obtained from digital medical records and prescription software.

Results

N = 365 patients were included (64.1% female), mean (SD) age 14.5 (2.04) years, with primary depression, anxiety or obsessive-compulsive disorder. No suicides occurred. When comparing the 6-w

SUBMITTER: Sorensen JO 

PROVIDER: S-EPMC9292826 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature