Reproductive toxicity assessment of alkyl dimethyl benzyl ammonium chloride and didecyl dimethyl ammonium chloride in CD® rats.

ABSTRACT:

Aim

To determine the potential of alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) to induce reproductive toxicity in CD® rats in two independent 2-generation reproduction studies conducted according to Good Laboratory Practices and standardized testing guidelines.

Materials and methods

Male and female rats (parents and offspring) were allowed continual free access to diets containing concentrations of ADBAC (0, 300, 1,000, or 2,000 ppm) or DDAC (0, 300, 750, or 1,500 ppm), beginning with F₀ generation adults at 10 weeks prior to breeding.

Results

No clinical signs of toxicity were observed in parental rats or their offspring in either study. Dietary exposure of parental rats to ADBAC or DDAC at the highest conce

SUBMITTER: Hostetler KA 

PROVIDER: S-EPMC9292890 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature