Drug exposure misclassification in pharmacoepidemiology: Sources and relative impact.

ABSTRACT:

Background

Drug exposure assessment based on dispensing data can be misclassified when patients do not adhere to their therapy or when information about over-the-counter drugs is not captured in the study database. Previous research has considered hypothetical sensitivity and specificity values, whereas this study aims to assess the impact of literature-based real values of exposure misclassification.

Methods

A synthetic cohort study was constructed based on the proportion of exposure theoretically captured in a database (range 0.5-1.0) and the level of adherence (0.5-1.0). Three scenarios were explored: nondifferential misclassification, differential misclassification (misclassifications dependent on an unmeasured risk factor doubling the outcome risk), and nondifferential

SUBMITTER: Hempenius M 

PROVIDER: S-EPMC9292927 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature