Rates of longitudinal change in ¹⁸ F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease.

ABSTRACT:

Introduction

Longitudinal positron emission tomography (PET) studies of tau accumulation in Alzheimer's disease (AD) have noted reduced increases or frank decreases in tau signal. We investigated how such reductions related to analytical confounds and disease progression markers in atypical AD.

Methods

We assessed regional and interindividual variation in longitudinal change on ¹⁸ F-flortaucipir PET imaging in 24 amyloid beta (Aβ)+ patients with atypical, early-onset amnestic or non-amnestic AD plus 62 Aβ- and 132 Aβ+ Alzheimer's Disease Neuroimaging Initiative (ADNI) participants.

Results

In atypical AD, ¹⁸ F-flortaucipir uptake slowed or declined over time in areas with high baseline signal and older, more impaired individuals. ADNI participant

SUBMITTER: Phillips JS 

PROVIDER: S-EPMC9292954 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature