Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a food allergen driven disease that is accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction allowing transepithelial food allergen permeation. Nutraceuticals, such as short-chain fatty acids (SCFAs) that restore barrier function and increase immune fitness may be a promising tool in the management of EoE. Here, we investigated the effects of the SCFAs acetate, propionate, and butyrate on an IL-13-compromised human esophageal epithelial barrier, including the mechanisms involved.

Methods

An air-liquid interface culture model of differentiated human EPC2-hTERT (EPC2) was used to study whether SCFAs could restore barrier function after IL-13-induced impairment. Esophageal epithelial barrier function wa

SUBMITTER: Kleuskens MTA 

PROVIDER: S-EPMC9293003 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature