Early melanoma invasivity correlates with gut fungal and bacterial profiles.

ABSTRACT:

Background

The microbiome is emerging as a crucial player of the immune checkpoint in cancer. Melanoma is a highly immunogenic tumour, and the composition of the gut microbiome has been correlated to prognosis and evolution of advanced melanoma and proposed as a biomarker for immune checkpoint therapy.

Objectives

We investigated the gut fungal and bacterial compositions in early-stage melanoma and correlated microbial profiles with histopathological features.

Methods

Sequencing of bacterial 16S rRNA and the fungal internal transcribed spacer region was performed on faecal samples of patients with stage I and II melanoma, and healthy controls. A meta-analysis with gut microbiota data from patients with metastatic melanoma was also carried out.

Results

We found a

SUBMITTER: Vitali F 

PROVIDER: S-EPMC9293081 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature