Generation of a novel model of bioengineered human oral mucosa with increased vascularization potential.

ABSTRACT:

Objective

The aim of this study was to generate novel models of bioartificial human oral mucosa with increased vascularization potential for future use as an advanced therapies medicinal product, by using different vascular and mesenchymal stem cell sources.

Background

Oral mucosa substitutes could contribute to the clinical treatment of complex diseases affecting the oral cavity. Although several models of artificial oral mucosa have been described, biointegration is a major issue that could be favored by the generation of novel substitutes with increased vascularization potential once grafted in vivo.

Methods

Three types of mesenchymal stem cells (MSCs) were obtained from adipose tissue, bone marrow, and dental pulp, and their in vitro potential was evaluated by ind

SUBMITTER: Blanco-Elices C 

PROVIDER: S-EPMC9293188 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature