Does preoperative locally applied estrogen treatment facilitate prolapse-associated symptoms in postmenopausal women with symptomatic pelvic organ prolapse? A randomised controlled double-masked, placebo-controlled, multicentre study.

ABSTRACT:

Objective

To evaluate whether locally applied vaginal estrogen affects prolapse-associated complaints compared with placebo treatment in postmenopausal women prior to surgical prolapse repair.

Design

Randomised, double-masked, placebo-controlled, multicentre study.

Setting

Urogynaecology unit at the Medical University of Vienna and University Hospital of Tulln.

Population

Postmenopausal women with symptomatic pelvic organ prolapse and planned surgical prolapse repair.

Methods

Women were randomly assigned local estrogen cream or placebo cream 6 weeks preoperatively.

Main outcome measures

The primary outcome was differences in subjective prolapse-associated complaints after 6 weeks of treatment prior to surgery, assessed with the comprehensive Germa

SUBMITTER: Marschalek ML 

PROVIDER: S-EPMC9293194 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature