Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration.

ABSTRACT: In order to identify peripheral biomarkers of impaired oxidative metabolism during exercise following a 10-day bed rest, 10 males performed an incremental exercise (to determine peak pulmonary V̇O₂ (V̇O₂ p)) and moderate-intensity exercises, before (PRE) and after (POST) bed rest. Blood flow response was evaluated in the common femoral artery by Eco-Doppler during 1 min of passive leg movements (PLM). The intramuscular matching between O₂ delivery and O₂ utilization was evaluated by near-infrared spectroscopy (NIRS). Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in isolated muscle fibres, and in vivo by NIRS by the evaluation of skeletal muscle V̇O₂ (V̇O₂ m) recovery kinetics. Resting V̇O

SUBMITTER: Zuccarelli L 

PROVIDER: S-EPMC9293208 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature