Patterns of transfusion burden in an unselected population of patients with myelodysplastic syndromes: A population-based study.

ABSTRACT:

Background

Ineffective hematopoiesis in patients with myelodysplastic syndromes (MDS) often results in transfusion dependence. The burden of frequent transfusions in the real-world MDS population is largely unknown.

Study design and methods

An observational, retrospective, population-based study, using the HemoBase registry, was performed including all patients diagnosed with MDS between 2005 and 2017 in Friesland, a province in the Netherlands with approximately 650,000 inhabitants. Detailed clinical information was collected from the electronic health records. Transfusion burden was classified according to the International Working Group 2018 criteria: not transfusion dependent, low (LTB), or high transfusion burden (HTB). Univariate and multivariable regression analyses w

SUBMITTER: Rozema J 

PROVIDER: S-EPMC9293228 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature