Pharmacokinetics of testosterone therapies in relation to diurnal variation of serum testosterone levels as men age.

ABSTRACT:

Background

To improve symptoms associated with testosterone deficiency, many testosterone therapies are available that aim to restore serum testosterone (T) levels to the normal physiologic range. The magnitude, frequency, and duration between peak and trough T concentrations vary with route of administration, and none reflect normal endogenous daily diurnal T variations.

Objective

To compare pharmacokinetic profiles of serum T from approved T formulations with endogenous diurnal T variations in young and older men, and to consider whether there may be value in mimicking the diurnal T rhythmicity with exogenous testosterone therapies as men age.

Materials and methods

A literature search of studies examining the diurnal variation of endogenous T in healthy men and men

SUBMITTER: Pastuszak AW 

PROVIDER: S-EPMC9293229 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature