A real-world study of alemtuzumab in a cohort of Italian patients.

ABSTRACT:

Background and purpose

Real-world data on alemtuzumab are limited and do not provide evidence of its effectiveness after various disease-modifying therapies (DMTs). Our aim was to provide real-world data on the impact of clinical variables and previous DMTs on clinical response to alemtuzumab.

Methods

Sixteen Italian multiple sclerosis centers retrospectively included patients who started alemtuzumab from January 2015 to December 2018, and recorded demographics, previous therapies, washout duration, relapses, Expanded Disability Status Scale (EDSS) score, and magnetic resonance imaging data. Negative binomial regression models were used to assess the effect of factors on annualized relapse (ARR) after alemtuzumab initiation.

Results

We studied 322 patients (mean age 3

SUBMITTER: Russo CV 

PROVIDER: S-EPMC9293282 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature