Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder.

ABSTRACT:

Background

Melanopsin retinal ganglion cell (mRGC)-mediated pupillary light reflex (PLR) abnormalities have been documented in several neurodegenerative disorders including Parkinson's disease. Overall, isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents the strongest prodromal risk factor for impending α-synucleinopathies.

Objectives

To quantitatively compare PLR and mRGC-mediated contribution to PLR in 16 iRBD patients and 16 healthy controls.

Methods

iRBD and controls underwent extensive neuro-ophthalmological evaluation and chromatic pupillometry. In iRBD, PLR metrics were correlated with clinical variables and with additional biomarkers including REM atonia index (RAI), DaTscan, and presence of phosphorylated-α-synuclein (p-α-syn) depositi

SUBMITTER: La Morgia C 

PROVIDER: S-EPMC9293298 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature