Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease.

ABSTRACT:

Introduction

We examine the role of brain apolipoprotein B (apoB) as a putative marker of early tau pathology and cognitive decline.

Methods

Cerebrospinal fluid (CSF) samples from cognitively normal and Alzheimer's disease (AD) participants were collected to measure protein levels of apoB and AD biomarkers amyloid beta (Aβ), t-tau and p-tau, as well as synaptic markers GAP43, SYNAPTOTAGMIN-1, synaptosome associated protein 25 (SNAP-25), and NEUROGRANIN. CSF apoB levels were contrasted with positron emission tomography (PET) scan measures of Aβ (18F-NAV4694) and Tau (flortaucipir) along with cognitive assessment alterations over 6 to 8 years.

Results

CSF apoB levels were elevated in AD participants and correlated with t-tau, p-tau, and the four synaptic markers in pre-

SUBMITTER: Picard C 

PROVIDER: S-EPMC9293308 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature