Comparing the sensitivities of two screening tests in nonblinded randomized paired screen-positive trials with differential screening uptake.

ABSTRACT: Before a new screening test can be used in routine screening, its performance needs to be compared to the standard screening test. This comparison is generally done in population screening trials with a screen-positive design where participants undergo one or both screening tests after which disease verification takes place for those positive on at least one screening test. We consider the randomized paired screen-positive design of Alonzo and Kittelson where participants are randomized to receive one of the two screening tests and only participants with a positive screening test subsequently receive the other screening test followed by disease verification. The tests are usually offered in an unblinded fashion in which case the screening uptake may differ between arms, in particular when

SUBMITTER: van de Ven PM 

PROVIDER: S-EPMC9293348 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature