The effect of chemotherapy on the exposure-response relation of abiraterone in metastatic castration-resistant prostate cancer.

ABSTRACT:

Aims

To assess whether the exposure-response relation for abiraterone is different in pre-chemotherapy patients compared to post-chemotherapy patients with metastatic castration-resistant prostate cancer (mCRPC).

Methods

Data were collected from three clinical studies in mCRPC patients treated with abiraterone acetate. Cox regression analysis was used to determine the relation between abiraterone exposure and survival (progression-free survival [PFS] and overall survival [OS]). An interaction term was used to test whether chemotherapy pretreatment was an effect modifier. To investigate the effect of the previously defined exposure threshold of 8.4 ng/mL on survival, Kaplan-Meier analysis was used.

Results

In total, 98 mCRPC patients were included, of which 78 were pre

SUBMITTER: Boerrigter E 

PROVIDER: S-EPMC9293353 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature