Pregabalin poisoning: Evaluation of dose-toxicity relationship.

ABSTRACT:

Context

Pregabalin poisoning is mostly benign, although coma and convulsions occasionally occur.

Aim

To determine the dose-toxicity relationship of pregabalin.

Methods

Dose-toxicity data of isolated pregabalin poisonings were collected from (1) a prospective study performed by the Dutch Poisons Information Centre (4 April 2014 to 4 October 2016) and from (2) case reports and case series reported in literature. Poisonings were graded using the Poisoning Severity Score (PSS) and the relationship between dose (mg kg^-1 ) and PSS was evaluated.

Results

In our study (n = 21 patients), the most commonly observed symptoms were drowsiness (62%), confusion (29%) and apathy (24%). PSS was none in three (14%), minor in 15 (71%), and moderate in three patients (1

SUBMITTER: Rietjens SJ 

PROVIDER: S-EPMC9293434 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature