Identification and Validation of a Potential Stemness-Associated Biomarker in Hepatocellular Carcinoma.

ABSTRACT:

Background

Cancer stem cells (CSCs) are typically related to metastasis, recurrence, and drug resistance in malignant tumors. However, the biomarker and mechanism of CSCs need further exploration. This study is aimed at comprehensively depicting the stemness characteristics and identify a potential stemness-associated biomarker in hepatocellular carcinoma (HCC).

Methods

The data of HCC patients from The Cancer Genome Atlas (TCGA) were collected and divided based on the mRNA expression-based stemness index (mRNAsi) in this study. Weighted gene coexpression network analysis (WGCNA) and the protein-protein interaction (PPI) network were performed, and the genes were screened through the Cytoscape software. Then, we constructed a prognostic expression signature using the multiva

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9293570 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature