Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adults.

ABSTRACT:

Background/aims

Accumulating evidence suggests a link between non-alcoholic fatty liver disease (NAFLD) and brain health. However, population-based evidence on the association between NAFLD and dementia remains unclear. This study was conducted to determine the association between NAFLD and incident dementia.

Methods

The study population included 608,994 adults aged ≥60 years who underwent health examinations between 2009 and 2010. Data were collected from the Korean National Health Insurance Service database. NAFLD was assessed using the fatty liver index (FLI). A Cox proportional hazards regression model was used to determine the association between NAFLD and dementia.

Results

During the 6,495,352 person-years of follow-up, 48,538 participants (8.0%) developed incid

SUBMITTER: Jeong S 

PROVIDER: S-EPMC9293607 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature