Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.

ABSTRACT: The bacterial stringent response involves wide-ranging metabolic reprogramming aimed at increasing long-term survivability during stress conditions. One of the hallmarks of the stringent response is the production of a set of modified nucleotides, known as alarmones, which affect a multitude of cellular pathways in diverse ways. Production and degradation of these molecules depend on the activity of enzymes from the RelA/SpoT homologous family, which come in both bifunctional (containing domains to both synthesize and hydrolyze alarmones) and monofunctional (consisting of only synthetase or hydrolase domain) variants, of which the structure, activity, and regulation of the bifunctional RelA/SpoT homologs have been studied most intensely. Despite playing an important role in guanosine nucle

SUBMITTER: Bisiak F 

PROVIDER: S-EPMC9293644 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature