Update and elucidation of Plasmodium kinomes: Prioritization of kinases as potential drug targets for malaria.

ABSTRACT: Malaria is a tropical disease caused by Plasmodium spp. and transmitted by the bite of infected Anopheles mosquitoes. Protein kinases (PKs) play key roles in the life cycle of the etiological agent of malaria, turning these proteins attractive targets for antimalarial drug discovery campaigns. As part of an effort to understand parasite signaling functions, we report the results of a bioinformatics pipeline analysis of PKs of eight Plasmodium species. To date, no P. malariae and P. ovale kinome assemble has been conducted. We classified, curated and annotated predicted kinases to update P. falciparum, P. vivax, P. yoelii, P. berghei, P. chabaudi, and P. knowlesi kinomes published to date, as well as report for the first time the kinomes of P. ma

SUBMITTER: Borba JVVB 

PROVIDER: S-EPMC9293725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature