Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)

ABSTRACT: Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after heart disease. Targeting drugs, especially to specific genes and proteins involved in growth and survival of cancer cells, is the prime need of research world-wide. Indole moiety, which is a combination of aromatic-heterocyclic compounds, is a constructive scaffold for the development of novel leads. Owing to its bioavailability, high unique chemical properties and significant pharmacological behaviours, indole is considered as the most inquisitive scaffold for anticancer drug research. This is illustrated by the fact that the U.S. Food and Drug Administration (FDA) has recently approved several indole-based anticancer agents such as panobinostat, alectinib, sunitinib, osimertinib, anlotinib and n

SUBMITTER: Dhiman A 

PROVIDER: S-EPMC9293743 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature