The sodium proton exchanger NHE9 regulates phagosome maturation and bactericidal activity in macrophages.

ABSTRACT: Acidification of phagosomes is essential for the bactericidal activity of macrophages. Targeting machinery that regulates pH within the phagosomes is a prominent strategy employed by various pathogens that have emerged as major threats to public health. Nascent phagosomes acquire the machinery for pH regulation through a graded maturation process involving fusion with endolysosomes. Meticulous coordination between proton pumping and leakage mechanisms is crucial for maintaining optimal pH within the phagosome. However, relative to mechanisms involved in acidifying the phagosome lumen, little is known about proton leakage pathways in this organelle. Sodium proton transporter NHE9 is a known proton leakage pathway located on the endosomes. As phagosomes acquire proteins through fusions with

SUBMITTER: Shamroukh HS 

PROVIDER: S-EPMC9293770 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature