Hairy cell leukemia: a specific 17-gene expression signature points to new targets for therapy.

ABSTRACT:

Background

Hairy cell leukemia (HCL) is a rare chronic B cell malignancy, characterized by infiltration of bone marrow, blood and spleen by typical "hairy cells" that bear the BRAFV600E mutation. However, in addition to the intrinsic activation of the MAP kinase pathway as a consequence of the BRAFV600E mutation, the potential participation of other signaling pathways to the pathophysiology of the disease remains unclear as the precise origin of the malignant hairy B cells.

Materials and methods

Using mRNA gene expression profiling based on the Nanostring technology and the analysis of 290 genes with crucial roles in B cell lymphomas, we defined a 17 gene expression signature specific for HCL.

Results

Separate analysis of samples from classical and variant forms of ha

SUBMITTER: Maitre E 

PROVIDER: S-EPMC9293816 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature